Substrate stress relaxation regulates cell spreading.

  title={Substrate stress relaxation regulates cell spreading.},
  author={Ovijit Chaudhuri and Luo Gu and Max C. Darnell and Darinka D. Klumpers and Sidi A Bencherif and James C. Weaver and Nathaniel D Huebsch and David J Mooney},
  journal={Nature communications},
Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the ECM. However, these studies typically utilize purely elastic materials as substrates, whereas physiological ECMs are viscoelastic, and exhibit stress relaxation, so that cellular traction forces exerted by cells remodel the ECM. Here we investigate the influence of ECM stress relaxation on cell behaviour… CONTINUE READING
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