Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions.

@article{Ishihara2013SubstrateSR,
  title={Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions.},
  author={Seiichiro Ishihara and Motoaki Yasuda and Ichiro Harada and Takeomi Mizutani and Kazushige Kawabata and Hisashi Haga},
  journal={Experimental cell research},
  year={2013},
  volume={319 19},
  pages={2916-27}
}
Physical properties of the extracellular matrix (ECM) can control cellular phenotypes via mechanotransduction, which is the process of translation of mechanical stresses into biochemical signals. While current research is clarifying the relationship between mechanotransduction and cytoskeleton or adhesion complexes, the contribution of transcription factors to mechanotransduction is not well understood. The results of this study revealed that the transcription factor NF-κB, a major regulator… CONTINUE READING
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