Substrate stiffness modulates lung cancer cell migration but not epithelial to mesenchymal transition.

@article{Shukla2016SubstrateSM,
  title={Substrate stiffness modulates lung cancer cell migration but not epithelial to mesenchymal transition.},
  author={Vasudha C. Shukla and Natalia Higuita-Castro and Patrick S. Nana-Sinkam and Samir N Ghadiali},
  journal={Journal of biomedical materials research. Part A},
  year={2016},
  volume={104 5},
  pages={1182-93}
}
Biomechanical properties of the tumor microenvironment, including matrix/substrate stiffness, play a significant role in tumor evolution and metastasis. Epithelial to Mesenchymal Transition (EMT) is a fundamental biological process that is associated with increased cancer cell migration and invasion. The goal of this study was to investigate (1) how substrate stiffness modulates the migration behaviors of lung adenocarcinoma cells (A549) and (2) if stiffness-induced changes in cell migration… CONTINUE READING
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Effect of curing temperature and cross-linker to pre-polymer ratio on the viscoelastic properties of a PDMS elastomer

  • AL FirdausPrabowo, HS Hayley
  • Adv Mater Res
  • 2015

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