Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen-GAG scaffold.

Abstract

Anchorage-dependent cells respond to the mechanical and physical properties of biomaterials. One such cue is the mechanical stiffness of a material. We compared the osteogenic potential of collagen-glycosaminoglycan (CG) scaffolds with varying stiffness for up to 6 weeks in culture. The mechanical stiffness of CG scaffolds were varied by cross-linking by… (More)
DOI: 10.1016/j.actbio.2010.06.001

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Cite this paper

@article{Keogh2010SubstrateSA, title={Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen-GAG scaffold.}, author={Michael B Keogh and Fergal J O'Brien and Jacqueline S. Daly}, journal={Acta biomaterialia}, year={2010}, volume={6 11}, pages={4305-13} }