Substrate specificity of the rat liver Na+-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells.

@article{Schroeder1998SubstrateSO,
  title={Substrate specificity of the rat liver Na+-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells.},
  author={Alice Schroeder and Uta Eckhardt and Bruno Stieger and Ronald E. Tynes and Claudio D. Schteingart and Alan Frederick Hofmann and Peter Meier and Bruno Hagenbuch},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1998},
  volume={274 2},
  pages={G370-G375}
}
It has been proposed that the hepatocellular Na+-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes. In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver Na+-taurocholate cotransporting polypeptide (Ntcp) may transport only taurocholate. To characterize its… CONTINUE READING