Substrate specificity of the human UDP‐glucuronosyltransferase UGT2B4 and UGT2B7

@article{Barr2007SubstrateSO,
  title={Substrate specificity of the human UDP‐glucuronosyltransferase UGT2B4 and UGT2B7},
  author={Lydia Barr{\'e} and Sylvie Fournel‐Gigleux and Moshe Finel and Patrick Netter and Jacques Magdalou and Mohamed Ouzzine},
  journal={The FEBS Journal},
  year={2007},
  volume={274}
}
The human UDP‐glucuronosyltransferase (UGT) isoforms UGT2B4 and UGT2B7 play a major role in the detoxification of bile acids, steroids and phenols. These two isoforms present distinct but overlapping substrate specificity, sharing common substrates such as the bile acid hyodeoxycholic acid (HDCA) and catechol‐estrogens. Here, we show that in UGT2B4, substitution of phenylalanine 33 by leucine suppressed the activity towards HDCA, and impaired the glucuronidation of several substrates, including… 
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