Substrate specificity of small-intestinal lactase. Assessment of the role of the substrate hydroxyl groups.

@article{RiveraSagredo1992SubstrateSO,
  title={Substrate specificity of small-intestinal lactase. Assessment of the role of the substrate hydroxyl groups.},
  author={Alfonso Rivera-Sagredo and F Javier Ca{\~n}ada and Ofelia Nieto and Jes{\'u}s Jim{\'e}nez-Barbero and Manuel Mart{\'i}n-Lomas},
  journal={European journal of biochemistry},
  year={1992},
  volume={209 1},
  pages={
          415-22
        }
}
Lactase-phlorizin hydrolase is a disaccharidase present in the small intestine of mammals. This enzyme has two active sites, one being responsible for the hydrolysis of lactose. Lactase activity is thought to be selective towards glycosides with a hydrophilic aglycon. In this work, we report a systematic study on the importance of each hydroxyl group in the substrate molecule for lactase activity. For this purpose, all of the monodeoxy derivatives of methyl beta-lactoside and other lactose… CONTINUE READING

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