Substrate specificity of acetoxy derivatives of coumarins and quinolones towards Calreticulin mediated transacetylation: investigations on antiplatelet function.

@article{Kathuria2012SubstrateSO,
  title={Substrate specificity of acetoxy derivatives of coumarins and quinolones towards Calreticulin mediated transacetylation: investigations on antiplatelet function.},
  author={Abha Kathuria and N. Priya and Karam Chand and Prabhjot Singh and Anjali Gupta and Sarah Jalal and Shilpi Gupta and Hanumantharao Guru Raj and Sunil K. Sharma},
  journal={Bioorganic & medicinal chemistry},
  year={2012},
  volume={20 4},
  pages={1624-38}
}
Calreticulin transacetylase (CRTAase) is known to catalyze the transfer of acetyl group from polyphenolic acetates (PA) to certain receptor proteins (RP), thus modulating their activity. Herein, we studied for the first time the substrate specificity of CRTAase towards N-acetylamino derivatives of coumarins and quinolones. This study is endowed with antiplatelet action by virtue of causing CRTAase catalyzed activation of platelet Nitric Oxide Synthase (NOS) by way of acetylation leading to the… CONTINUE READING

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