Substrate specificity and mutational analysis of Kluyveromyces lactis gamma-toxin, a eukaryal tRNA anticodon nuclease.

@article{Jain2011SubstrateSA,
  title={Substrate specificity and mutational analysis of Kluyveromyces lactis gamma-toxin, a eukaryal tRNA anticodon nuclease.},
  author={Ruchi Jain and Michael G Poulos and Julien Gros and Anupam K. Chakravarty and Stewart Shuman},
  journal={RNA},
  year={2011},
  volume={17 7},
  pages={1336-43}
}
tRNA anticodon damage inflicted by the Kluyveromyces lactis γ-toxin underlies an RNA-based innate immune system that distinguishes self from nonself species. γ-toxin arrests the growth of Saccharomyces cerevisiae by incising a single phosphodiester 3' of the wobble base of tRNA(Glu(UUC)) to generate a break with 2',3'-cyclic phosphate and 5'-OH ends… CONTINUE READING