Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.

@article{Vinge2007SubstrateSO,
  title={Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function.},
  author={Leif Erik Vinge and Kjetil Wessel Andressen and Toril Attramadal and Geir \Oystein Andersen and Mohammed Shakil Ahmed and Karsten C. Peppel and Walter J Koch and Neil J. Freedman and Finn Olav Levy and Tor Skomedal and J Osnes and H{\aa}vard Attramadal},
  journal={Molecular pharmacology},
  year={2007},
  volume={72 3},
  pages={582-91}
}
The closely related G protein-coupled receptor kinases GRK2 and GRK3 are both expressed in cardiac myocytes. Although GRK2 has been extensively investigated in terms of regulation of cardiac beta-adrenergic receptors, the substrate specificities of the two GRK isoforms at G protein-coupled receptors (GPCR) are poorly understood. In this study, the substrate specificities of GRK2 and GRK3 at GPCRs that control cardiac myocyte function were determined in fully differentiated adult cardiac… CONTINUE READING
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