Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells.

@article{EstradaRodgers1998SubstrateSO,
  title={Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells.},
  author={L Estrada-Rodgers and G{\'e}rald L{\'e}vy and Wendell W. Weber},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 5},
  pages={502-5}
}
Two human acetyl-CoA:arylamine N-acetyltransferases (NAT1 and NAT2) have been identified. Therapeutic and carcinogenic agents that are substrates for these isoenzymes (including isoniazid, sulfamethazine, p-aminobenzoic acid, 5-aminosalicyclic acid, and 2-aminofluorene) have been used to evaluate the role of the N-acetylation polymorphisms of NAT1 and NAT2 in the treatment of disease and differential risk of various cancers among individuals of differing acetylator phenotypes. The mouse is… CONTINUE READING

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References

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Characterization of congenic mouse ( NAT 2 * ) and human ( NAT 1 * ) N - acetyltransferases

JH deLeón
1996

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