Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs.

@article{Lund2006SubstrateSO,
  title={Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs.},
  author={Elsebet Lund and James Eric Dahlberg},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={2006},
  volume={71},
  pages={
          59-66
        }
}
Each step in the biogenesis of microRNAs (miRNAs) depends on recognition of a correct substrate and efficient transport or processing of that RNA. Exportin5 (Exp5) and Dicer are proteins that mediate two key steps in this cascade, the nuclear export and cytoplasmic processing of microRNA precursor (pre-miRNAs). Xenopus laevis oocytes, eggs, and embryos constitute convenient experimental systems in which to study the substrate specificity of these proteins because specific RNAs or proteins can… CONTINUE READING

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