Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria.

@article{Tsai2013SubstrateSI,
  title={Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria.},
  author={Ming-Feng Tsai and P Mccarthy and Christopher Miller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 15},
  pages={5898-902}
}
The bacterial antiporter GadC plays a central role in the glutamate (Glu)-dependent acid resistance system, which protects enteric bacteria against the extreme acidity of the human stomach. Upon acid shock, GadC imports Glu into the cytoplasm, where Glu decarboxylases consume a cytoplasmic proton, which ends up as a "virtual" proton in the decarboxylated product γ-aminobutyric acid (GABA) and is then exported via GadC. It was therefore proposed that GadC counters intracellular acidification by… CONTINUE READING