Substrate requirements and kinetic analysis of the cortisol effects on uridine uptake and incorporation by mouse lymphoma P1798 cells in vitro.

Abstract

Cortisol markedly suppressed in vitro utilization of uridine-3 H by corticoid-sensitive mouse lymphoma P1798 cells. Corticoid-resistant cells were not affected. Inhibition did not depend on reduced uptake of exogenous carbohydrate precursors since similar effects were obtained in glucose-free, pyruvate-free medium. Omission of glucose and pyruvate per se… (More)

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