Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.

  title={Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.},
  author={Stefan Sikorra and Tina Henke and Thierry Galli and Thomas Binz},
  journal={The Journal of biological chemistry},
  volume={283 30},
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) inhibit neurotransmitter release by proteolyzing a single peptide bond in one of the three soluble N-ethylmaleimide-sensitive factor attachment protein receptors SNAP-25, syntaxin, and vesicle-associated membrane protein (VAMP)/synaptobrevin. TeNT and BoNT/B, D, F, and G of the seven known BoNTs cleave the synaptic vesicle protein VAMP/synaptobrevin. Except for BoNT/B and TeNT, they cleave unique peptide bonds, and prior work suggested… CONTINUE READING


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