Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective.

@article{Hur2006SubstrateRB,
  title={Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective.},
  author={Sun Hur and Robert Michael Stroud and Janet S Finer-Moore},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 51},
  pages={38969-73}
}
Through all kingdoms of life RNAs are modified as, or after, they are synthesized. The types and sites of modification are often conserved, implying conservation of function. Many of these modifications are located at key functional regions of the ribosome or other RNAs. The enzymes that carry out the modifications exhibit unique or limited multisite… CONTINUE READING