Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection

@inproceedings{Valds2016SubstratePO,
  title={Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection},
  author={James J. Vald{\'e}s and Alejandro Cabezas-Cruz and Radek {\vS}{\'i}ma and Philip T. Butterill and Daniel Rů{\vz}ek and Patricia A Nuttall},
  booktitle={Scientific reports},
  year={2016}
}
Evolution has provided ticks with an arsenal of bioactive saliva molecules that counteract host defense mechanisms. This salivary pharmacopoeia enables blood-feeding while enabling pathogen transmission. High-throughput sequencing of tick salivary glands has thus become a major focus, revealing large expansion within protein encoding gene families. Among these are lipocalins, ubiquitous barrel-shaped proteins that sequester small, typically hydrophobic molecules. This study was initiated by… CONTINUE READING
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