Substrate path in the AcrB multidrug efflux pump of Escherichia coli.

  title={Substrate path in the AcrB multidrug efflux pump of Escherichia coli.},
  author={Fasahath Husain and Hiroshi Nikaido},
  journal={Molecular microbiology},
  volume={78 2},
A major tripartite multidrug efflux pump of Escherichia coli, AcrAB-TolC, confers resistance to a wide variety of compounds. The drug molecule is captured by AcrB probably from the periplasm or the periplasm/inner membrane interface, and is passed through AcrB and then TolC to the medium. Currently, there exist numerous crystallographic and mutation data concerning the regions of AcrB and its homologues that may interact with substrates. Starting with these data, we devised fluorescence assays… CONTINUE READING

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