Substrate-mediated remodeling of methionine transport by multiple ubiquitin-dependent mechanisms in yeast cells.

@article{Menant2006SubstratemediatedRO,
  title={Substrate-mediated remodeling of methionine transport by multiple ubiquitin-dependent mechanisms in yeast cells.},
  author={Alexandra Menant and R{\'e}gine Barbey and Dominique C. Thomas},
  journal={The EMBO journal},
  year={2006},
  volume={25 19},
  pages={
          4436-47
        }
}
Plasma membrane transport of single amino-acid methionine in yeast is shown to be mediated by at least seven different permeases whose activities are transcriptionaly and post-transcriptionaly regulated by different ubiquitin-dependent mechanisms. Upon high extracellular methionine exposure, three methionine-permease genes are repressed while four others are induced. SCF(Met30), SCF(Grr1) and Rsp5 ubiquitin ligases are the key actors of the ubiquitin-dependent remodeling of methionine transport… CONTINUE READING
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