Substrate-mediated regulation of cullin neddylation.

@article{Chew2007SubstratemediatedRO,
  title={Substrate-mediated regulation of cullin neddylation.},
  author={E Chew and Thilo Hagen},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 23},
  pages={17032-40}
}
Cullin-based E3 ligases are a large family of multi-subunit ubiquitin ligases with diverse cellular functions, including the regulation of the cell cycle, of the DNA damage response, and of various transcription factors. These ligases are composed of one of six mammalian cullin homologs (Cul1, Cul2, Cul3, Cul4a, Cul4b, and Cul5), the Ring finger containing protein Roc1/Rbx1, and cullin homolog-specific adaptor and substrate recognition subunits. To be active, cullin-based ligases require the… CONTINUE READING

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