Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: critical considerations.

Abstract

Excessive glutamate release (mediated by reversed uptake) or impaired reuptake contributes to the etiopathology of many neurodegenerative disorders. Thus great effort has been devoted to the discovery of agents that can interfere with high-affinity Na+-dependent glutamate transport, with the aim of finding new therapeutics against neurodegenerative diseases… (More)

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