Substrate inhibition of carnitine palmitoyltransferase by palmitoyl-CoA and activation by phospholipids and proteins.


When carnitine palmitoyltransferase is purified it shows increasing substrate inhibition by palmitoyl-CoA as the protein content of the assay mixture is decreased. The purified enzyme is stimulated by addition of phospholipids (phosphatidylcholine, cardiolipin) and proteins (albumin, fatty acid-binding protein, lambda-globulin) to the reaction mixture. The… (More)


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