Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases.

  title={Substrate-induced ubiquitylation and endocytosis of yeast amino acid permeases.},
  author={Kassem Ghaddar and Ahmad Merhi and Elie Saliba and Eva-Maria Krammer and Martine Pr{\'e}vost and Bruno Andr{\'e}},
  journal={Molecular and cellular biology},
  volume={34 24},
Many plasma membrane transporters are downregulated by ubiquitylation, endocytosis, and delivery to the lysosome in response to various stimuli. We report here that two amino acid transporters of Saccharomyces cerevisiae, the general amino acid permease (Gap1) and the arginine-specific permease (Can1), undergo ubiquitin-dependent downregulation in response to their substrates and that this downregulation is not due to intracellular accumulation of the transported amino acids but to transport… CONTINUE READING
Highly Cited
This paper has 28 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
19 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…