Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.

@article{Steinsapir2000SubstrateinducedDO,
  title={Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.},
  author={J. Steinsapir and Antonio Carlos Mugayar Bianco and Christoph Buettner and John W. Harney and P. R. Larsen},
  journal={Endocrinology},
  year={2000},
  volume={141 3},
  pages={
          1127-35
        }
}
Type 2 iodothyronine deiodinase (D2) catalyzes the first step in thyroid hormone action, the deiodination of T4 to T3. Endogenous D2 activity is posttranslationally regulated by substrate that accelerates its degradation through the ubiquitin-proteasome pathway. To understand how D2 activity correlates with D2 protein during its normal decay and rT3-induced down-regulation, HEK-293 cells, transiently expressing human D2, were labeled with Na75SeO3 and then treated with 100 microM cycloheximide… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 50 CITATIONS

FILTER CITATIONS BY YEAR

2000
2018

CITATION STATISTICS

  • 3 Highly Influenced Citations

  • Averaged 1 Citations per year over the last 3 years

Similar Papers

Loading similar papers…