Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase.

@article{Bhat2011SubstrateinducedCC,
  title={Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase.},
  author={Javaid Yousuf Bhat and Roopa Venkatachala and Hemalatha Balaram},
  journal={The FEBS journal},
  year={2011},
  volume={278 19},
  pages={3756-68}
}
GMP synthetase is a glutamine amidotransferase that incorporates ammonia derived from glutamine into the nucleotide xanthosine 5'-monophosphate (XMP) to form guanosine 5'-monophosphate (GMP). Functional coordination of domains in glutamine amidotransferases leads to upregulation of glutamine hydrolysis in the presence of acceptor substrates and is a common… CONTINUE READING