Substrate discrimination by formamidopyrimidine-DNA glycosylase: distinguishing interactions within the active site.

@article{PerlowPoehnelt2004SubstrateDB,
  title={Substrate discrimination by formamidopyrimidine-DNA glycosylase: distinguishing interactions within the active site.},
  author={Rebecca A Perlow-Poehnelt and Dmitry O. Zharkov and Arthur P. Grollman and Suse Broyde},
  journal={Biochemistry},
  year={2004},
  volume={43 51},
  pages={16092-105}
}
Reactive oxygen species are byproducts of normal aerobic respiration and ionizing radiation, and they readily react with DNA to form a number of base lesions, including the mutagenic 8-oxo-7,8-dihydroguanine (8-oxoG), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), 4,6-diamino-5-formamidopyrimidine (FapyA), and 8-oxo-7,8-dihydroadenine (8-oxoA). Such oxidative lesions are removed by the base excision repair pathway, which is initiated by DNA glycosylases such as the formamidopyrimidine-DNA… CONTINUE READING

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