Corpus ID: 24956143

Substrate cycles in metabolic regulation and in heat generation.

  title={Substrate cycles in metabolic regulation and in heat generation.},
  author={Eric A. Newsholme and B. Crabtree},
  journal={Biochemical Society symposium},
1. The presence of substrate cycles in tissues has been demonstrated by direct isotope methods in recent years. This demonstration has provided the impetus for a reappraisal of the roles of substrate cycling in metabolic regulation and in heat production. These aspects of substrate cycling are discussed in this paper. The relationship between near-equilibrium reactions and substrate cycles is emphasized, since this provides a basis for the derivation of a function describing in precise… Expand
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