Substrate concentration affects the in vitro metabolism of 17-hydroxyprogesterone by ovaries of the carp, Cyprinus carpio

Abstract

Carp ovarian tissue was incubated with 3H-17-hydroxyprogesterone in the presence of 0, 0.1, 1, 10, and 100 μg ml−1 unlabeled 17-hydroxyprogesterone. The pattern of metabolites formed showed a marked variation with substrate concentration. Formation of glucuronide and sulphate conjugates was important only at low substrate concentration. At high substrate… (More)
DOI: 10.1007/BF00003436

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