Substrate binding and catalysis in heme peroxidases.

  title={Substrate binding and catalysis in heme peroxidases.},
  author={Andrew T. Smith and Nigel C. Veitch},
  journal={Current opinion in chemical biology},
  volume={2 2},
Peroxidase-catalysed reactions are being analysed at an increasingly advanced level of structural and mechanistic sophistication. A significant development in this respect has been the long-anticipated solution of crystal structures for several plant peroxidases and a fungal peroxidase complexed to benzhydroxamic acid. New insights into peroxide binding and catalysis have been obtained through site-directed mutagenesis, a technique also crucial to recent progress in understanding the diversity… CONTINUE READING