Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity.

@article{Kemp1994SubstrateAP,
  title={Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity.},
  author={Bruce E. Kemp and Michael W Parker and S H Hu and Tony Tiganis and Colin House},
  journal={Trends in biochemical sciences},
  year={1994},
  volume={19 11},
  pages={440-4}
}
Protein crystallography has revealed that protein kinases have extended protein-substrate-binding grooves associated with their active sites. Some protein kinases are autoinhibited by a mechanism in which part of their structure, termed a pseudosubstrate, occupies the active site. Substrates and pseudosubstrates occupy overlapping regions within the extended substrate-binding groove, making multiple specific electrostatic and non-polar contacts. With masterly economy, Nature has exploited the… CONTINUE READING

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