Substrate and pH effects on glutamine synthesis in rat liver. Consequences for acid-base regulation.

@article{Almond1991SubstrateAP,
  title={Substrate and pH effects on glutamine synthesis in rat liver. Consequences for acid-base regulation.},
  author={Michael K. Almond and Ann J Smith and Robert Donald Cohen and Richard A Iles and Geraldine Flynn},
  journal={The Biochemical journal},
  year={1991},
  volume={278 ( Pt 3)},
  pages={709-14}
}
Switching in acidosis of hepatic nitrogen disposal from urea synthesis to NH4+ and net glutamine production was demonstrated in the isolated perfused livers of starved male Wistar rats. Lactate was preferred to glucose as the substrate for the carbon skeleton of glutamine synthesized over the pH range 6.9-7.5. This is necessary if the switch away from a proton-producing process (ureagenesis) in acidosis is to constitute an acid-base regulating system intrinsic to the liver. Glutamine balance… CONTINUE READING