Substrate and inhibitor specificity of the cloned human 11 beta-hydroxysteroid dehydrogenase type 2 isoform.

Abstract

The 11 beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme is thought to confer specificity on the mineralocorticoid receptor by inactivating glucocorticoids in mineralocorticoid target organs. The cloned 11 beta HSD2 displayed Michaelis constant values for corticosterone and cortisol of 5.1 and 61 nM, respectively. Linearity in the dose-response… (More)

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@article{Ferrari1996SubstrateAI, title={Substrate and inhibitor specificity of the cloned human 11 beta-hydroxysteroid dehydrogenase type 2 isoform.}, author={P. Ferrari and R. E. Smith and Jonas Funder and Zygmunt S. Krozowski}, journal={The American journal of physiology}, year={1996}, volume={270 5 Pt 1}, pages={E900-4} }