Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells.

@article{Wang1996SubstrateAI,
  title={Substrate and inhibitor specificities of the monocarboxylate transporters of single rat heart cells.},
  author={X. Wang and A. Levi and A. Halestrap},
  journal={The American journal of physiology},
  year={1996},
  volume={270 2 Pt 2},
  pages={
          H476-84
        }
}
We have used the intracellular pH-sensitive fluorescent dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (BCECF) to characterize the substrate and inhibitor specificity of monocarboxylate transport into isolated rat heart cells. Further evidence was obtained for the presence of two lactate carriers present in heart cells (Wang et al., Biochem. J. 290: 249-258, 1993) both distinct from the recently cloned monocarboxylate transporter isoform 1 (MCT-1) found in many other cell types. Only one… Expand
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