Substrate and dilution effects on the inhibition of acetylcholinesterase by carbamates.

@article{Winteringham1966SubstrateAD,
  title={Substrate and dilution effects on the inhibition of acetylcholinesterase by carbamates.},
  author={F P Winteringham and K S Fowler},
  journal={The Biochemical journal},
  year={1966},
  volume={101 1},
  pages={127-34}
}
1. The kinetics of acetylcholinesterase (EC 3.1.1.7) activity and its inhibition by eserine or by Sevin (1-naphthyl N-methylcarbamate) have been studied over the substrate concentration range 5x10(-8) to 2.5x10(-2)m. 2. Equations are given for inhibition as a function of time, substrate and inhibitor concentrations, and the relevant parameters determined at 25 degrees and 37 degrees . 3. The observed and calculated effects of time, dilution, substrate addition and enzyme concentration were in… CONTINUE READING

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