Substrate and Product Dependence of Force and Shortening in Fast and Slow Smooth Muscle

@article{Lfgren2001SubstrateAP,
  title={Substrate and Product Dependence of Force and Shortening in Fast and Slow Smooth Muscle},
  author={Mia L{\"o}fgren and Ulf P Malmqvist and Anders Arner},
  journal={The Journal of General Physiology},
  year={2001},
  volume={117},
  pages={407 - 418}
}
To explore the molecular mechanisms responsible for the variation in smooth muscle contractile kinetics, the influence of MgATP, MgADP, and inorganic phosphate (P(i)) on force and shortening velocity in thiophosphorylated "fast" (taenia coli: maximal shortening velocity Vmax = 0.11 ML/s) and "slow" (aorta: Vmax = 0.015 ML/s) smooth muscle from the guinea pig were compared. P(i) inhibited active force with minor effects on the V(max). In the taenia coli, 20 mM P(i) inhibited force by 25%. In the… CONTINUE READING

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MgADP binding to cross bridges reduces rigor force in smooth muscle

  • A Khromov, A V Somlyo, A P Somlyo
  • Biophys. J
  • 2000

Effects of ATP, ADP and inorganic phosphate on force and shortening velocity differ between fast and slow smooth muscles

  • U Malmqvist, M Löfgren, A Arner
  • Biophys. J
  • 1999

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