Substrate ambiguous enzymes within the Escherichia coli proteome offer different evolutionary solutions to the same problem.

@article{Yip2013SubstrateAE,
  title={Substrate ambiguous enzymes within the Escherichia coli proteome offer different evolutionary solutions to the same problem.},
  author={Sylvia Hsu-Chen Yip and Ichiro Matsumura},
  journal={Molecular biology and evolution},
  year={2013},
  volume={30 9},
  pages={2001-12}
}
Many enzymes exhibit some catalytic promiscuity or substrate ambiguity. These weak activities do not affect the fitness of the organism under ordinary circumstances, but can serve as potential evolutionary precursors of new catalytic functions. We wondered whether different proteins with the same substrate ambiguous activity evolve differently under identical selection conditions. Patrick et al. (Patrick WM, Quandt EM, Swartzlander DB, Matsumura I. 2007. Multicopy suppression underpins… CONTINUE READING