Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression

@inproceedings{Ebata2017SubstrateSI,
  title={Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression},
  author={Takahiro Ebata and Yasumasa Mitsui and Wataru Sugimoto and Miho Maeda and Keigo Araki and Hiroaki Machiyama and Ichiro Harada and Yasuhiro Sawada and Hideaki Fujita and Hiroaki Hirata and Keiko Kawauchi},
  booktitle={BioMed research international},
  year={2017}
}
The physical properties of the extracellular matrix (ECM), such as stiffness, are involved in the determination of the characteristics of cancer cells, including chemotherapy sensitivity. Resistance to chemotherapy is often linked to dysfunction of tumor suppressor p53; however, it remains elusive whether the ECM microenvironment interferes with p53… CONTINUE READING