Substrate Controlled Divergence in Polyketide Synthase Catalysis

Abstract

Biochemical characterization of polyketide synthases (PKSs) has relied on synthetic substrates functionalized as electrophilic esters to acylate the enzyme and initiate the catalytic cycle. In these efforts, N-acetylcysteamine thioesters have typically been employed for in vitro studies of full PKS modules as well as excised domains. However, substrate… (More)
DOI: 10.1021/ja511743n

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