Substrate Competition as a Source of Ultrasensitivity in the Inactivation of Wee1


The mitotic regulators Wee1 and Cdk1 can inactivate each other through inhibitory phosphorylations. This double-negative feedback loop is part of a bistable trigger that makes the transition into mitosis abrupt and decisive. To generate a bistable response, some component of a double-negative feedback loop must exhibit an ultrasensitive response to its… (More)
DOI: 10.1016/j.cell.2007.01.039

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