Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect Type IV pilus assembly, dynamics and associated functions.

@article{Aas2007SubstitutionsIT,
  title={Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect Type IV pilus assembly, dynamics and associated functions.},
  author={Finn Erik Aas and Hanne Cecilie Winther-Larsen and Matthew C Wolfgang and Stephan A. Frye and Cecilia L\ovold and Norbert Roos and Jos P M van Putten and Michael Koomey},
  journal={Molecular microbiology},
  year={2007},
  volume={63 1},
  pages={69-85}
}
Type IV pili (Tfp) are multifunctional surface appendages expressed by many Gram negative species of medical, environmental and industrial importance. The N-terminally localized, so called alpha-helical spine is the most conserved structural feature of pilin subunits in these organelles. Prevailing models of pilus assembly and structure invariably implicate its importance to membrane trafficking, organelle structure and related functions. Nonetheless, relatively few studies have examined the… CONTINUE READING

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