Substitutional bias confounds inference of cyanelle origins from sequence data

@article{Lockhart1992SubstitutionalBC,
  title={Substitutional bias confounds inference of cyanelle origins from sequence data},
  author={Peter J. Lockhart and Christopher J. Howe and Donald A Bryant and T. J. Beanland and Anthony W. D. Larkum},
  journal={Journal of Molecular Evolution},
  year={1992},
  volume={34},
  pages={153-162}
}
Available molecular and biochemical data offer conflicting evidence for the origin of the cyanelle of Cyanophora paradoxa. We show that the similarity of cyanelle and green chloroplast sequences is probably a result of these two lineages independently developing the same pattern of directional nucleotide change (substitutional bias). This finding suggests caution should be exercised in the interpretation of nucleotide sequence analyses that appear to favor the view of a common endosymbiont for… CONTINUE READING

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