Substitution rates of organelle and nuclear genes in sharks: implicating metabolic rate (again).

@article{Martin1999SubstitutionRO,
  title={Substitution rates of organelle and nuclear genes in sharks: implicating metabolic rate (again).},
  author={Andrew Philip Martin},
  journal={Molecular biology and evolution},
  year={1999},
  volume={16 7},
  pages={
          996-1002
        }
}
Rates of nucleotide substitution for nuclear genes are thought to be governed primarily by the number of germ line replication events (the so-called "generation time" hypothesis). In contrast, rates of mitochondrial DNA evolution appear to be set primarily by DNA damage pathways of mutation mediated by mutagenic by-products of oxidative phosphorylation (the so-called "metabolic-rate" hypothesis). Comparison of synonymous substitution rates estimated for the mitochondrial cytochrome b gene and… CONTINUE READING
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