Substitution rate of the hepatitis B virus surface gene.

  title={Substitution rate of the hepatitis B virus surface gene.},
  author={Hans L. Zaaijer and Shifra T Bouter and Hein J. Boot},
  journal={Journal of viral hepatitis},
  volume={15 4},
Molecular epidemiology of hepatitis B virus (HBV) often relies on the comparison of HBV surface (S) gene sequences, although little is known about the substitution rate of the HBV S-gene. In this study, we compared HBV S-gene sequences in longitudinal sample pairs of 40 untreated, chronically HBV-infected patients, spanning 210 years of cumulative follow-up. The 40 patients included HBV e-antigen positive and negative persons; with HBV DNA levels ranging from 10(3) to 10(9) cps/mL and belonging… CONTINUE READING
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