Substitution of temazepam and midazolam in pentobarbital-dependent rats

@article{Yutrzenka1989SubstitutionOT,
  title={Substitution of temazepam and midazolam in pentobarbital-dependent rats},
  author={G. Yutrzenka and G. Patrick and W. Rosenberger},
  journal={Physiology \& Behavior},
  year={1989},
  volume={46},
  pages={55-60}
}
The ability of temazepam and midazolam to substitute for pentobarbital and thus maintain the physical dependence state was used to assess the potential dependence liability of these two benzodiazepine compounds. Male Sprague-Dawley rats, weighing 175-200 g and having ad lib access to food and water, were determined to be dependent on pentobarbital following 12 days of continuous, intraperitoneal infusion of pentobarbital using an escalating drug infusion schedule. On day 13 (substitution phase… Expand
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