Substitution of temazepam and midazolam in pentobarbital-dependent rats

  title={Substitution of temazepam and midazolam in pentobarbital-dependent rats},
  author={G. Yutrzenka and G. Patrick and W. Rosenberger},
  journal={Physiology \& Behavior},
The ability of temazepam and midazolam to substitute for pentobarbital and thus maintain the physical dependence state was used to assess the potential dependence liability of these two benzodiazepine compounds. Male Sprague-Dawley rats, weighing 175-200 g and having ad lib access to food and water, were determined to be dependent on pentobarbital following 12 days of continuous, intraperitoneal infusion of pentobarbital using an escalating drug infusion schedule. On day 13 (substitution phase… Expand
Substitution of psychoactive drugs in pentobarbital-dependent rats.
The data supports the view that the substitution of compounds for pentobarbital, in dependent rats, is limited to those compounds which, presumably, possess similar mechanisms of action in the CNS. Expand
Diltiazem alters some withdrawal signs in pentobarbital-dependent rats
Male, Sprague-Dawley rats were made dependent on pentobarbital sodium (PB) by continuous, IP infusion of PB for 13 days. On Day 14, a 72-hour PB-free period began during which body weight, 24-hourExpand
Evaluation of the abuse liability of aminorex.
It is indicated that aminorex is a psychomotor stimulant that would be predicted to have significant d-amphetamine-like abuse liability in humans. Expand
Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats.
Data suggest that the abuse liability of flunitrazepam is comparable to that of other benzodiazepines. Expand
Preclinical abuse potential assessment of the anticonvulsant zonisamide
Zonisamide (Zonegran®) is a broad‐spectrum antiepileptic agent that shares some pharmacological properties with other anticonvulsants, including phenytoin, carbamazepine, and valproic acid, but isExpand
Problems of drug dependence 1997: proceedings of the 59th annual scientific meeting.
This history of the DEC was written to reacquaint the members of the CPDD with the origins of this unusual committee, to inform them about its current activities, and to relate what services the committee offers to them. Expand
Problems of Drug Dependence, 2002: Proceedings of the 64th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
This study evaluated the benefits of a brief training and treatment-services matching technology designed to give clinical meaning and value to a research-based assessment, and thereby improveExpand
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L’invention concerne un procede et des therapies associees pour traiter l’obesite ou un trouble de l’alimentation associe en administrant un compose actif du recepteur GABA-A, tel qu’unExpand


Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.
Spontaneous locomotor activity was significantly greater in pentobarbital-dosed animals during withdrawal than in saline-infused control rats, and infusion of pentobarBital is a quick and reliable method for the study of barbiturate dependence in the rat. Expand
Diazepam and pentobarbital dependence in the rat.
The data indicate that diazepam and pentobarbital produce different types of dependencies in the rat and are not equivalent in suppressing signs of abstinence. Expand
Cross-physical dependence liability of psychotropic drugs in rats dependent on barbiturates.
It was found that it was possible to evaluate precisely the cross-physical dependence on sedative-hypnotics by means of investigation for the method of suppression of WSP and the relapse of such signs upon their withdrawal. Expand
Dependence liability of several sedative-hypnotic agents evaluated in monkeys.
Dependence liability of 10 drugs was tested in rhesus monkeys and benzoctamine and perlapine were found to be dependence-free drugs. Expand
Barbiturate physical dependence in mice: effects of neuroleptics and diazepam on the withdrawal syndrome.
Diazepam (8 mg/kg) quickly and effectively reduced the incidence of withdrawal symptoms in phenobarbital dependent C57BL/6J male mice, and chlorpromazine and haloperidol were approximately equally potent in their effects; this would suggest that their antidopaminergic effects were not the primary mechanism of action for the increased incidence of withdrawals. Expand
By means of the substitution technique, data were obtained on the potency and duration of physical dependence action of each of ten related drugs of the morphine, codeine series. From comparisons ofExpand
Interaction of depressant, convulsant, and anticonvulsant barbiturates with the [3H]diazepam binding site of the benzodiazepine-GABA-receptor-ionophore complex.
  • M. Ticku
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1981
Barbiturates with pharmacological profiles similar to that of the benzodiazepine-GABA-receptor-ionophore complex enhance diazepam binding to rat brain membranes, and the ability of these antagonists to block barbiturate enhancement suggests that barbiturate may increase diazepAM binding by acting on the Benzodiazepines. Expand
GABA‐Benzodiazepine‐Barbiturate Receptor Interactions
  • R. Olsen
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1981
Evidence supports the model for a complex containing receptor sites for GABA, benzodiazepines, and picrotoxininl barbiturates, as well as the chloride ionophore, and thus the relevance of GABA to the actions of the other drugs. Expand
A simplified method of evaluating dose-effect experiments.
The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data. Expand
A new device for the rapid measurement of impaired motor function in mice
The new screen test used in this paper uses untrained mice in a 60 sec test which measures the ability of mice to either climb to the top of or cling to the bottom of a horizontal screen, and the ED50 values obtained are similar to those obtained with the rotarod. Expand