Substitution of temazepam and midazolam in pentobarbital-dependent rats

@article{Yutrzenka1989SubstitutionOT,
  title={Substitution of temazepam and midazolam in pentobarbital-dependent rats},
  author={Gerald J. Yutrzenka and Graham A. Patrick and W Rosenberger},
  journal={Physiology \& Behavior},
  year={1989},
  volume={46},
  pages={55-60}
}
View on Elsevier
doi.org
8 Citations
Background Citations
2
Methods Citations
3

8 Citations

Substitution of psychoactive drugs in pentobarbital-dependent rats.
Diltiazem alters some withdrawal signs in pentobarbital-dependent rats
Evaluation of the abuse liability of aminorex.
Behavioral effects of flunitrazepam: reinforcing and discriminative stimulus effects in rhesus monkeys and prevention of withdrawal signs in pentobarbital-dependent rats.
Problems of drug dependence 1997: proceedings of the 59th annual scientific meeting.
TLDR
This history of the DEC was written to reacquaint the members of the CPDD with the origins of this unusual committee, to inform them about its current activities, and to relate what services the committee offers to them.
Utilisation d’hypno-sedatifs pour traiter l’obesite ou maintenir la perte de poids
L’invention concerne un procede et des therapies associees pour traiter l’obesite ou un trouble de l’alimentation associe en administrant un compose actif du recepteur GABA-A, tel qu’un…
Problems of Drug Dependence, 2002: Proceedings of the 64th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
This study evaluated the benefits of a brief training and treatment-services matching technology designed to give clinical meaning and value to a research-based assessment, and thereby improve…
Preclinical abuse potential assessment of the anticonvulsant zonisamide
TLDR
Zonisamide was tested in animal models of the subjective and reinforcing effects of central nervous system (CNS) depressant drugs and evaluated for physical dependence liability, supporting the prediction that zonisamide would have low abuse liability.

References

SHOWING 1-10 OF 13 REFERENCES
Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat.
TLDR
Spontaneous locomotor activity was significantly greater in pentobarbital-dosed animals during withdrawal than in saline-infused control rats, and infusion of pentobarBital is a quick and reliable method for the study of barbiturate dependence in the rat.
Dependence liability of several sedative-hypnotic agents evaluated in monkeys.
TLDR
Dependence liability of 10 drugs was tested in rhesus monkeys and benzoctamine and perlapine were found to be dependence-free drugs.
Barbiturate physical dependence in mice: effects of neuroleptics and diazepam on the withdrawal syndrome.
  • J. Belknap
  • Psychology, Biology
    Clinical toxicology
  • 1978
TLDR
Diazepam (8 mg/kg) quickly and effectively reduced the incidence of withdrawal symptoms in phenobarbital dependent C57BL/6J male mice, and chlorpromazine and haloperidol were approximately equally potent in their effects; this would suggest that their antidopaminergic effects were not the primary mechanism of action for the increased incidence of withdrawals.
THE EFFECTS OF CERTAIN CHEMICAL CHANGES ON THE ADDICTION CHARACTERISTICS OF DRUGS OF THE MORPHINE, CODEINE SERIES
TLDR
None of the types of chemical modification mentioned in this report caused reductions in both duration and intensity of physical dependence action.
Interaction of depressant, convulsant, and anticonvulsant barbiturates with the [3H]diazepam binding site of the benzodiazepine-GABA-receptor-ionophore complex.
  • M. Ticku
  • Biology, Chemistry
    Biochemical pharmacology
  • 1981
GABA‐Benzodiazepine‐Barbiturate Receptor Interactions
  • R. Olsen
  • Biology
    Journal of neurochemistry
  • 1981
TLDR
Evidence supports the model for a complex containing receptor sites for GABA, benzodiazepines, and picrotoxininl barbiturates, as well as the chloride ionophore, and thus the relevance of GABA to the actions of the other drugs.
A simplified method of evaluating dose-effect experiments.
TLDR
The method provides means for the rapid test of parallelism of two curves and easy computation of relative potency with its confidence limits and its accuracy is commensurate with the nature of dose-per cent effect data.
A new device for the rapid measurement of impaired motor function in mice
A Substitution Technique for Determining Barbiturate-like Physiological Dependence Capacity in the Dog1
Introduction to statistics for the behavioral sciences
...
...