Substitution of Val for Met at residue 239 of platelet glycoprotein Ib alpha in Japanese patients with platelet-type von Willebrand disease.

@article{Takahashi1995SubstitutionOV,
  title={Substitution of Val for Met at residue 239 of platelet glycoprotein Ib alpha in Japanese patients with platelet-type von Willebrand disease.},
  author={Hiroki Takahashi and Mitsuru Murata and Takanori Moriki and H. Anbo and Tatsuo Furukawa and Kohji Nikkuni and Akira Shibata and Makoto Handa and Yohko Kawai and Kiyoaki Watanabe},
  journal={Blood},
  year={1995},
  volume={85 3},
  pages={727-33}
}
Genomic DNA was studied from four patients with platelet-type von Willebrand disease (vWD) from two Japanese families previously reported. The entire coding region of platelet glycoprotein (GP) Ib alpha, a component of the platelet receptor for von Willebrand factor (vWF), was examined by polymerase chain reaction (PCR) followed by direct DNA sequence analysis. A single point mutation was found in all patients resulting in substitution of Val (GTG) for Met (ATG) at residue 239 of GPIb alpha… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…