Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval.

  title={Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval.},
  author={Nicolas Ansermot and Ozg{\"u}r Albayrak and Juerg Schlaepfer and Severine Crettol and Marina Croquette-Krokar and Michel Bourquin and J D{\'e}glon and M. Faouzi and N. Scherbaum and Chin B. Eap},
  journal={Archives of internal medicine},
  volume={170 6},
BACKGROUND Methadone is administered as a chiral mixture of (R,S)-methadone. The opioid effect is mainly mediated by (R)-methadone, whereas (S)-methadone blocks the human ether-à-go-go-related gene (hERG) voltage-gated potassium channel more potently, which can cause drug-induced long QT syndrome, leading to potentially lethal ventricular tachyarrhythmias. METHODS To investigate whether substitution of (R,S)-methadone by (R)-methadone could reduce the corrected QT (QTc) interval, (R,S… CONTINUE READING
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