Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval.

  title={Substitution of (R,S)-methadone by (R)-methadone: Impact on QTc interval.},
  author={Nicolas Ansermot and Ozg{\"u}r Albayrak and Juerg Schlaepfer and Severine Crettol and Marina Croquette-Krokar and Michel Bourquin and J D{\'e}glon and M. Faouzi and N. Scherbaum and Chin B. Eap},
  journal={Archives of internal medicine},
  volume={170 6},
BACKGROUND Methadone is administered as a chiral mixture of (R,S)-methadone. The opioid effect is mainly mediated by (R)-methadone, whereas (S)-methadone blocks the human ether-à-go-go-related gene (hERG) voltage-gated potassium channel more potently, which can cause drug-induced long QT syndrome, leading to potentially lethal ventricular tachyarrhythmias. METHODS To investigate whether substitution of (R,S)-methadone by (R)-methadone could reduce the corrected QT (QTc) interval, (R,S… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 35 extracted citations

Opioid Dependence

Springer International Publishing • 2018
View 2 Excerpts

Pharmacogenetics of Methadone Response

Molecular Diagnosis & Therapy • 2017
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 34 references


ICH Expert Workin
ICH Harmonised Tripartite Guideline. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for nonantiarrhythmic drugs: E14. 2005;1-14. .pdf. Accessed January 20, • 2009
View 3 Excerpts

Similar Papers

Loading similar papers…