Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit.

@article{Chaperon2003SubstitutionFP,
  title={Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit.},
  author={Fr{\'e}d{\'e}rique Chaperon and Wolfgang M{\"u}ller and Yves P Auberson and Mark D. Tricklebank and Hans C. Neijt},
  journal={Behavioural pharmacology},
  year={2003},
  volume={14 5-6},
  pages={477-87}
}
The non-competitive NMDA receptor antagonist phencyclidine (PCP) is known to produce a discriminative stimulus in rats. The first aim of the present study was to investigate which NMDA receptor subtype(s) is involved in this effect of PCP. Rats were trained to discriminate PCP (2 mg/kg; i.p.) from saline in a two lever operant task. The NMDA channel blocker, (+)MK-801 (0.1 mg/kg; i.p.) and the competitive NMDA receptor antagonist SDZ 220-581 (3 mg/kg; i.p.) produced 76% of PCP-lever selection… CONTINUE READING
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