Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells.

@article{IglesiasGato2011SubstitutionAC,
  title={Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells.},
  author={Diego Iglesias-Gato and Shasha Zheng and John N. Flanagan and Lan Jiang and Atsushi Kittaka and Toshiyuki Sakaki and Keiko Yamamoto and Toshimasa Itoh and Nathan K. Lebrasseur and Gunnar Norstedt and Tai C. Chen},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2011},
  volume={127 3-5},
  pages={269-75}
}
The active form of vitamin D(3), 1α,25-dihydroxyvitamin D(3)(1α,25(OH)(2)D(3)), has anti-proliferative and anti-invasive activities in prostate cancer cells. Because of 1α,25(OH)(2)D(3) therapeutic potential in treating cancers, numerous analogues have been synthesized with an attempt to increase anti-proliferative and/or decrease calcemic properties. Among… CONTINUE READING