Substitution Reactions of Platinum(II)-Nucleobase Complexes by Associative Mechanism Involving Pseudorotation of the Five-Coordinate Intermediate.

Substitution reactions of N7-platinated guanosine and adenosine complexes {[Pt(dien)(Guo-N7)](2+) (1), [Pt(dien)(Ado-N7)](2+) (2), dien = diethylenetriamine} by thiourea (tu) and I(-) have been studied in aqueous solution in the pH range 1.4-8.3 at different temperatures. Reactions of both complexes with I(-) follow the usual associative two-path mechanism… CONTINUE READING